Don’t over-optimize

Modern browsers do a lot of optimization under-the-hood at runtime. A lot of times, if you are optimizing then you are just wasting your time. There are good resources for seeing where optimization is lacking. Target those in the meantime, until they are fixed if they can be.

Bad:

// On old browsers, each iteration with uncached `list.length` would be costly
// because of `list.length` recomputation. In modern browsers, this is optimized.
for (let i = 0; len = list.length; i < len; i++) {
  // ...
}

Good:

for (let i = 0; i < list.length; i++) {
  // ...
}